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KMID : 0605620150220020063
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Journal of Korean Society of Biological Psychiatry
2015 Volume.22 No. 2 p.63 ~ p.77
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Effects of the Combination Herbal Extract on Working Memory and White Matter Integrity in Healthy Individuals with Subjective Memory Complaints : A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
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Kwon O-Ran
Lee Sun-Ho
Ban Soon-Hyun
Im Joo-Yeon
Lee Doo-Suk
Lee Eun-Hee
Kim Joo-Hee
Lim Soo-Mee
Lee Sang-Gon
Kang Il-Hyang
Kim Kyung-Hee
Yoon Su-Jung
Lee Sun-Hea
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Abstract
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Objectives : The combination extract of four kinds of herbs, Gastrodia elata, Liriope platyphylla, Dimocarpus longan, and Salvia miltiorrhiza, has shown to have memory improving effects in mice. The aim of this study was to investigate the efficacy and safety of the herbal mixture for improving working memory as well as microstructural changes in white matter integrity in individuals with subjective memory complaints.
Methods : Seventy-five individuals with subjective memory complaints were assigned to receive either placebo (n = 15) or herbal mixture (low-dose group, n = 30 and high-dose group, n = 30) supplementation in an 8-week, randomized, double-blind, placebo-controlled clinical trial. Changes in working memory performance and fractional anisotropy (FA) values reflecting white matter integrity from baseline to 8-week endpoint were assessed.
Results : The herbal mixture group showed an increase in working memory performance compared to the placebo group (p for interaction = 0.001). In addition, the herbal mixture group showed an increase in FA values in the temporo-parietal regions (corrected p < 0.05), which are crucially involved in working memory function and are among the most affected regions in patients with cognitive impairments.
Conclusions : Findings from this study indicate that the herbal mixture may be a promising therapeutic option for individuals with subjective memory complaints.
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KEYWORD
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Combination herbal extract, Working memory, Diffusion tensor imaging, White matter integrity, Subjective memory complaints
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